The hippocampus plays an important role in multiple cognitive processes, particularly declarative memory 1, 2 its structural compromise is a hallmark of prevalent neurological and psychiatric disorders, such as temporal lobe epilepsy 3, Alzheimer’s disease 4, 5, depression 6, and schizophrenia 7. Highly segregated connectional properties have promoted its use as a model system. The hippocampus has been a focus of neuroscience research for decades. The dataset can inform neuroimaging assessments of the mesiotemporal lobe and help to develop segmentation algorithms relevant for basic and clinical neurosciences. Segmentation was guided by consistent intensity and morphology characteristics of the densely myelinated molecular layer together with few geometry-based boundaries flexible to overall mesiotemporal anatomy, and achieved excellent intra-/inter-rater reliability (Dice index ≥90/87%). The protocol divided the hippocampal formation into three subregions: subicular complex, merged Cornu Ammonis 1, 2 and 3 (CA1-3) subfields, and CA4-dentate gyrus (CA4-DG). Data were acquired on a widely available 3 Tesla MRI system using a 32 phased-array head coil.
HIPPOCAMPUS ANATOMY SULCUS CORONAL HIGH RESOLUTION T1 MRI MANUAL
Here, we share manual labels and associated high-resolution MRI data (MNI-HISUB25 submillimetric T1- and T2-weighted images, detailed sequence information, and stereotaxic probabilistic anatomical maps) based on 25 healthy subjects. These approaches, however, demand time-consuming manual segmentation that relies heavily on anatomical expertise. Advances in high-field MRI allow for the non-invasive identification of hippocampal substructure. The hippocampus is composed of distinct anatomical subregions that participate in multiple cognitive processes and are differentially affected in prevalent neurological and psychiatric conditions.